VE-PTP promoter activity in developing mouse kidneys.

<p><b>(A through L)</b> β-galactosidase histochemistry of developing VE-PTP^tlacZ/+ mouse kidneys. In embryonic kidneys, evident VE-PTP activity is observed in penetrating and ingrowing renal arteries (black arrows in panels A, B, C, D, and J) and maturing glomeruli (G) (panels D and J). VE-PTP promoter activity is also observed in developing medullar vessels (arrowheads in panel G). In postnatal kidneys, VE-PTP promoter activity is observed in renal arterial vessels (panels E and F), maturing glomeruli (G) (panels E, F, and K), and medullary vessels (arrow heads in panels H and I) and tubular subpopulations (arrows in panels H and I). Note: VE-PTP promoter activity is observed in the cells intermittently distributed around developing glomeruli and tubules (red arrowheads in panel J) and in peri-tubular capillaries in postnatal kidneys (red arrows in panel K). The peritubular capillary VE-PTP promoter activity is down-regulated in 3-week old mouse kidney (panel L). RA, renal artery; G, glomerulus; IA, interlobular artery; V, venous vessel; T, developing tubules. Scale bar, 100 μm in A through I; 50 μm in J through L.