Network and pairwise meta-analyses for acute coronary syndrome of oral antidiabetic drugs.

<p>The analyses of acute coronary syndrome risk included data from acute coronary syndrome, acute myocardial infarction or unstable angina counted as severe adverse events. Traditional pairwise (upper right side) and network (lower left side) meta-analytic results are depicted for the cardiovascular-related mortality. Outcome of meta-analysis is expressed as relative risks (RRs) (95% confidence intervals) in the case of pairwise meta-analysis and (95% credible intervals) in the case of network meta-analysis. For the pairwise meta-analysis, RRs of less than 1 indicate that the drug located in the column is safer. For the network meta-analysis, RRs of less than 1 indicate that the drug located in the row is safer. Bold results indicate statistical significance. The analyses included data from 51 RCTs but the sum of total studies is 52 because two trials split in two. Rosiglitazone Evaluated for Cardiovascular Outcomes and regulation of Glycaemia in Diabetes (RECORD) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0177646#pone.0177646.ref031" target="_blank">31</a>] split in two after searching reports as separated by metformin or sulfonylurea at ClinicalTrials.gov website. TZD: thiazolidinedione. DPP4: dipeptidyl peptidase-4. SGLT2: sodium glucose cotransporter-2.