Myeloid cell reconstitution in spleen and bone marrow. Percentage of myeloid cells (CD33+) in spleen (A) and bone marrow (B). Gating strategy is shown in Additional file 4: Figure S4. Each symbol represents an individual mouse; for each time point post-transplantation, data are derived from two different groups of mice, which are indicated by different symbols (spleen: open/closed, bone marrow: different colors); each group was transplanted with cells derived from a different cord blood. (TIF 104 kb
Figure S6. Humanized bone marrow gating strategies. The percentage of lymphocytes was enumerated bas...
Gating strategies for LSKs. BM cells collected from WT or IL-21R−/− C57BL/6 mice were treated in vit...
showing cell marker panels of Sca1, CD73, CD105, CD29, and CD45 in bone-marrow derived MSCs. A cell ...
Reconstitution of adult B-ALL in NSI mice. (A) Left, spleens from of an NSI mouse engrafted with B-A...
Cells expanded on P-MSCs gave rise to persistent engraftment in NOD/SCID mice. a Superior multi-line...
Treatment of adult HSCs with NO donor reduces their engraftment ability. The donor cell chimerism in...
Treatment of adult HSCs with NO donor does not induce lineage bias in regenerated blood cells. Lin− ...
Table S1. Cell components in graft. Figure S1. HLA-DR−/lowCD33+CD16− eMDSCs demonstrated superior im...
Single cell assays of primary adult B-ALL cells. (A) Each NSI mouse was injected with a single prima...
Abstract Background Humanized mice (hu mice) are based on the transplantation of hematopoietic stem ...
Figure S3. Antibody array: representative detection of 96 different mouse cytokines. The profiles of...
Showing the representative gating strategy for flow cytometric analysis. Cells were gated based on t...
Frequency of CD34+ AML cells is greater in newborn NSG pups than adult NSG mice. Magnetically sorted...
Representative bivariate dot plots and single parameter histograms showing the ex vivo expression pr...
Figure S4. Spleen TCRβ chain gene usage. a Individual TCRβ chain gene families usage in NSG-cmah−/− ...
Figure S6. Humanized bone marrow gating strategies. The percentage of lymphocytes was enumerated bas...
Gating strategies for LSKs. BM cells collected from WT or IL-21R−/− C57BL/6 mice were treated in vit...
showing cell marker panels of Sca1, CD73, CD105, CD29, and CD45 in bone-marrow derived MSCs. A cell ...
Reconstitution of adult B-ALL in NSI mice. (A) Left, spleens from of an NSI mouse engrafted with B-A...
Cells expanded on P-MSCs gave rise to persistent engraftment in NOD/SCID mice. a Superior multi-line...
Treatment of adult HSCs with NO donor reduces their engraftment ability. The donor cell chimerism in...
Treatment of adult HSCs with NO donor does not induce lineage bias in regenerated blood cells. Lin− ...
Table S1. Cell components in graft. Figure S1. HLA-DR−/lowCD33+CD16− eMDSCs demonstrated superior im...
Single cell assays of primary adult B-ALL cells. (A) Each NSI mouse was injected with a single prima...
Abstract Background Humanized mice (hu mice) are based on the transplantation of hematopoietic stem ...
Figure S3. Antibody array: representative detection of 96 different mouse cytokines. The profiles of...
Showing the representative gating strategy for flow cytometric analysis. Cells were gated based on t...
Frequency of CD34+ AML cells is greater in newborn NSG pups than adult NSG mice. Magnetically sorted...
Representative bivariate dot plots and single parameter histograms showing the ex vivo expression pr...
Figure S4. Spleen TCRβ chain gene usage. a Individual TCRβ chain gene families usage in NSG-cmah−/− ...
Figure S6. Humanized bone marrow gating strategies. The percentage of lymphocytes was enumerated bas...
Gating strategies for LSKs. BM cells collected from WT or IL-21R−/− C57BL/6 mice were treated in vit...
showing cell marker panels of Sca1, CD73, CD105, CD29, and CD45 in bone-marrow derived MSCs. A cell ...