IL-22Rα expression in a representative mouse skin and human skin biopsy.

<p>(A) Five-week-old male HR-1 hairless mice (n = 20) were irradiated with 100 J/m² UVB for 13 weeks (5 times/week) on the dorsal skin. (B) The buttocks of healthy men were irradiated with 10 mJ/cm² UVB. After 24 h, skin samples were biopsied from non-irradiated and irradiated areas. Immunochemistry was used to detect the expression of IL-22Rα in these mouse and human skin samples, and hematoxylin and eosin staining was performed to confirm skin inflammation (not shown). Scale bar = 200 μm.