Additional file 2: Figure S2. of ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

BRAF inhibitors do not induce phosphorylation of PDH in resistant melanoma cells. Western blot analysis of untreated A375, A375 cells resistant to Vemurafenib (A375-R) and under constant presence of 1 μM of PLX4032 and A375 cells stimulated with 1 μM of PLX4032 for 24 h. α-Tubulin was used as loading control; representative blots of three biological replicates are shown. (PDF 102 kb