Model representation describing <i>I</i>_Kur and simulated voltage clamp.

<p><b>A</b> Steady-state activation and inactivation; <b>B</b> Time constants; <b>C</b> Current trace obtained from a simulated voltage clamp. Inserts: top right–voltage protocol; bottom right–experimental current traces; <b>D</b> I-V relationship. In the Fig the simulation data were shown using lines, and experimental data represented by points. Experimental data were taken from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005587#pcbi.1005587.ref002" target="_blank">2</a>]; specially, for <b>B</b> the time constants were derived from current traces from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005587#pcbi.1005587.ref002" target="_blank">2</a>] by fitting the activation phase of the current trace to a mono-exponential equation.