eNOS inhibition induces the expression and activity of anti-recovery mechanisms after cerebral ischemia.

<p>Acute L-NIO treatment increased nNOS (F = 7.44, df = 3; p = 0.0014) (A) and Nogo-A expression (B) in the ipsilateral hemisphere (F = 11.68 df = 3; p<0.0001) This increase was associated with a concomitant increase in JNK phosphorylation (F = 28.46, df = 3; p<0.0001) (C). Data presented as mean±SEM. Solid columns represent ipsilateral hemisphere, columns with stripes represent contralateral hemisphere. S refers to the ipsilateral hemisphere; NS refers to the contralateral hemisphere. a, b or A, B Pairs of means with different letters are significantly different from each other. n = 6–8 animals per group.