Glucose responses to a glucose load during performance of oral glucose tolerance test (OGTT) in control (A), FATZO mice (B) and the areas under the curve for both groups (C).

<p>An age-dependent impairment in glucose handling was apparent in FATZO mice compared to control mice in mice as young as 6 weeks. Glucose AUC (C) increased with age in FATZO mice (▲) compared to control mice (●) (two-way repeated measures, ANOVA * <i>p</i> < .05 when compared to control).