Comparison of the concentrations of the metabolites with VIP>1 among the MCF-7, MCF-7/shCK-α, MCF-7/TAM, and MCF-7/TAM/shCK-α cell groups.

<p>Increased lactate, glycine, phosphocholine, glutamine, and succinate in MCF-7/TAM relative to the other cell groups. Increased myo-inositol in MCF-7/shCK-α relative to the other cells. Non-detectable formate in MCF-7/TAM and MCF-7/TAM/shCK-α. Non-detectable fumarate in 7/shCK-α and MCF-7/TAM and MCF-7/TAM/shCK-α. Decreased AXP in MCF-7/shCK-α cells and MCF-7/TAM/shCK-α relative to MCF-7 and MCF-7/TAM. The spectra were normalized against total intensity and averaged over the samples in MCF-7, MCF-7/shCK-α, MCF-7/TAM and MCF-7/TAM/shCK-α. All values are presented as the mean ± standard error. *<i>p</i><0.05, ** 0.001<i><0.05, *** <i>p</i><0.001.</i>