<p>Mice treated with BLM (60 U/kg) were sacrificed on days 7 (N = 7), 10 (N = 12), 14 (N = 7), 21 (N = 12), and 28 (N = 6). (A) Dermal thickness was measured in the dorsal skin. (B) Hydroxyproline content was measured in skin tissues shown in (A). (C) Representative H&E (left) and MT (right) images of mouse skin treated with BLM (original magnification ×40). (D) Subcutaneous adipose layer thickness was measured in the dorsal skin.</p
<p>Comparison of the lung architecture in C57Bl/6 mice after BLM instillation (21st day of the exper...
<p>(A) The MLF were isolated from TERT CKO or WT mice at 21 days after BLM injection, and analyzed f...
model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microsphere
The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc...
<p>(A) The protocol for Figure 2B and 2C is shown. Bleomycin or PBS was locally injected in the back...
<div><p>The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclero...
<p>Total collagen in the (A) skin or (B) lungs of mice challenged daily with subcutaneous bleomycin ...
We have established a mouse model for scleroderma induced by repeated local injections of bleomycin ...
Systemic sclerosis (SSc) refers to an autoimmune disease, which is manifested by inflammation, vascu...
<p>(A) Outline of experimental design. Intradermal injection of saline, PDGF-BB alone, bleomycin alo...
Objective To test the antifibrotic effect of dermatan sulphate in a bleomycin-induced mouse model of...
BACKGROUND: The development of new therapies for hypertrophic scarring has been hampered by the lack...
<p>Smooth muscle increase was detected by α-smooth muscle actin staining (SMA) (A). Sirius red stain...
<p>Bleomycin treated mice given mesenchymal stem cells from human marrow (BM-MSC) and amnion (AM-MSC...
Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurab...
<p>Comparison of the lung architecture in C57Bl/6 mice after BLM instillation (21st day of the exper...
<p>(A) The MLF were isolated from TERT CKO or WT mice at 21 days after BLM injection, and analyzed f...
model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microsphere
The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc...
<p>(A) The protocol for Figure 2B and 2C is shown. Bleomycin or PBS was locally injected in the back...
<div><p>The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclero...
<p>Total collagen in the (A) skin or (B) lungs of mice challenged daily with subcutaneous bleomycin ...
We have established a mouse model for scleroderma induced by repeated local injections of bleomycin ...
Systemic sclerosis (SSc) refers to an autoimmune disease, which is manifested by inflammation, vascu...
<p>(A) Outline of experimental design. Intradermal injection of saline, PDGF-BB alone, bleomycin alo...
Objective To test the antifibrotic effect of dermatan sulphate in a bleomycin-induced mouse model of...
BACKGROUND: The development of new therapies for hypertrophic scarring has been hampered by the lack...
<p>Smooth muscle increase was detected by α-smooth muscle actin staining (SMA) (A). Sirius red stain...
<p>Bleomycin treated mice given mesenchymal stem cells from human marrow (BM-MSC) and amnion (AM-MSC...
Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurab...
<p>Comparison of the lung architecture in C57Bl/6 mice after BLM instillation (21st day of the exper...
<p>(A) The MLF were isolated from TERT CKO or WT mice at 21 days after BLM injection, and analyzed f...
model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microsphere