Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations - Fig 4

<p>Schematic representations of Goldbeter-Koshland dose-response curves with <i>K</i>₁ ≳ 1 and <i>K</i>₂ ≪ 1 (see equation in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180083#pone.0180083.s001" target="_blank">S1 Text</a>) shown in log-linear scale (A) and in log-log scale (B). The corresponding response coefficient (C) shows no local ultrasensitivity for low input values (i.e. <i>R</i> ∼ 1), but displays high local ultrasensitivity, even larger than the module’s Hill coefficient <i>n</i>_<i>H</i>, for intermediate input regions.