Overview of transcriptome changes in the six mutants.

<p><b>A)</b> Low-resolution map of transcript changes across Chromosome 6. The vertical axis of each plot is log2 scale. The top plot (black) shows levels of RNA in the 46<b>a</b> wild-type (WT) strain. The lower six plots (blue) show the fold change in RNA level relative to WT in each of the mutants. The horizontal axis shows the position in base pairs from the left end of Chromosome 6. The position of the <i>RIM15</i> gene is shown by a red bar below the <i>sen1</i>-WT trace. <b>B)</b> Metagene plot of relative RNA level changes across the length of all annotated protein-coding genes in each of the six mutants. The values are relative to the matched wild-type strain. The horizontal axis represents the percent distance along each ORF and the first 100 bp of the 3’-UTR. <b>C)</b> “Sawtooth” pattern of changes in RNA level across six ORFs on Chromosome 16 in the <i>hrp1</i> mutant. Genes above the chromosome line (Watson or “w” strand) are transcribed to the right, and those below the line (Crick or “c” strand) are transcribed to the left.