Chromosome 1 in aCGH.

<p>The 10 Mb moving average and the aberration calls by ADM2 (after raising threshold to 12, with FZ off) are plotted for each sample. Losses are green, gains are red. </p><p></p><p></p><p>(A) Brain DNA hybridised against PBL reference DNA. Cerebellar samples are orange, and FC green. The moving average of a male to female DNA reference hybridisation is also shown (dark blue).</p><p></p><p></p><p>(B) Genome isochores. GC content range for each 100 kb isochore is 30–65% (blue to orange).</p><p></p><p></p><p>(C) Cerebellar DNA hybridised against FC DNA of the same brain for three PD cases with overnight SC extraction. PD1 = purple, PD2 = black, PD4 = green. Data for PD2 are derived after combining the dye-flip hybridisation pair.</p><p></p><p></p><p>(D) Hybridisations between DNA from the same brain as follows.</p><p>(1–3) Hybridisations of SC-isolated cerebellar DNA, with Puregene-isolated DNA from same cerebellum as reference. (1) PD3, 5 mg SC; (2) PD3, 25mg SC; (3) PD4, 25 mg SC.</p><p>(4) PD1, Puregene-isolated DNA, cerebellar (test) with FC as reference. Note the absence of waves and losses. This sample combination, but with spin column extraction, had led to waves and losses (PD1 in panel C).</p><p></p><p></p><p></p> <p>(A) Brain DNA hybridised against PBL reference DNA. Cerebellar samples are orange, and FC green. The moving average of a male to female DNA reference hybridisation is also shown (dark blue).</p> <p>(B) Genome isochores. GC content range for each 100 kb isochore is 30–65% (blue to orange).</p> <p>(C) Cerebellar DNA hybridised against FC DNA of the same brain for three PD cases with overnight SC extraction. PD1 = purple, PD2 = black, PD4 = green. Data for PD2 are derived after combining the dye-flip hybridisation pair.</p> <p>(D) Hybridisations between DNA from the same brain as follows.</p> <p>(1–3) Hybridisations of SC-isolated cerebellar DNA, with Puregene-isolated DNA from same cerebellum as reference. (1) PD3, 5 mg SC; (2) PD3, 25mg SC; (3) PD4, 25 mg SC.</p> <p>(4) PD1, Puregene-isolated DNA, cerebellar (test) with FC as reference. Note the absence of waves and losses. This sample combination, but with spin column extraction, had led to waves and losses (PD1 in panel C).