Relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and hemodynamic parameters in patients with pulmonary hypertension (PH).

<p>Serum 25(OH)D levels and hemodynamic parameters were measured in 41 patients with PH, consisting of 12 patients with idiopathic or heritable pulmonary arterial hypertension (PAH) and 29 patients with chronic thromboembolic pulmonary hypertension (CTEPH). (A) Serum 25(OH)D levels in each PH classification. Serum 25(OH)D levels are shown as box plots, with bars denoting median values, boxes denoting interquartile ranges, and whiskers denoting ranges, excluding statistical outliers (●; >1.5 box lengths from either the 25th or 75th percentiles). Serum 25(OH)D levels of insufficiency (red line), deficiency (blue line), and the mean levels in Japanese adults (black broken line) are shown. (B)-(E) Correlations in 41 patients with PH were analyzed between 25(OH)D levels and mean pulmonary arterial pressure (PAP) (B), pulmonary vascular resistance (PVR) (C), cardiac output (D), and mean right atrial pressure (RAP) (E), respectively.