Co-ordinated spatial propagation of blood plasma clotting and fibrinolytic fronts - Fig 2

<p>Spatial kinetics of fibrin generation in the absence <b>(A)</b> or in the presence <b>(B)</b> of 50 nmol/L TPA. Spatial fibrin distribution is shown for 10^th (black line), 30^th (blue line) and 60^th (red line) minute of simulation. <b>(C)</b> Time course of clot growth/lysis front during simulation. <b>(D)</b> Scheme of blood coagulation cascade main reactions. Zymogens are shown as blue circles, activated proteins are shown as yellow circles. Inactive cofactors are shown as blue rectangles, activated cofactors are shown as cyan rectangles. Red arrows show activation, black arrows show transition from inactive to active form, and formation of complexes. Green arrows show inhibition. Double arc shows phospholipid surface that is required for complex formation or activation. PgA stands for plasminogen activator; FDP stands for fibrin degradation products.