PD149163 decreases operant responding for METH in mice.

<p>(A) Systemic injection (s.c.) of both doses of PD149163 resulted in a significant decrease in nose pokes (FR3) made during 2-hour operant METH self-administration sessions. * <i>P</i> < 0.05 versus saline, Dunnett’s multiple comparison test. (B) Both doses of PD149163 also produced a significant decrease in number of METH infusions. * <i>P</i> < 0.05 versus saline, Dunnett’s multiple comparison test.