Differential gene expression of patients who later develop Multiple Organ Dysfunction Syndrome (MODS).

<p>(A) Gene expression profiles of the 16 genes with the greatest difference in expression between MODS and those that did not develop MODS (NoMODS), which were also differentially expressed in the Critical versus Control analysis. The greatest differences in MODS versus NoMODS expression are seen in the hyperacute (0 hours) time point in all cases. (B) Coexpression network representation of all differentially expressed MODS genes. Coloured genes are those mapped to cell death and organismal survival pathways. Red: up-regulated; green: down-regulated. Two tightly correlated clusters are represented, with cell death represented across both clusters. There is an almost complete reversal of expression pattern of these genes between the hyperacute window and 24 hours postinjury.