Functional characteristics of miR-146a-5p and miR-146b-5p as proangiogenic miRNAs.

<p>(A) Knockdown of miR-146a-5p and miR-146b-5p in CAD ECFCs by miRZip. Scramble oligonucleotide was used as control (Ctrl). (B) The proangiogenic effects of miR-146a-5p and miR-146b-5p. Transwell cell migration (upper panel) and tube formation (lower panel) assays were conducted on CAD ECFCs transduced with miRZip anti-miR-146a-5p (middle panel) and anti-miR-146b-5p (right panel). (C) Quantification data of (B). (D) Overexpression of miR-146a-5p and miR-146b-5p in HLTY ECFCs. (E) Transwell cell migration (upper panel) and tube formation (lower panel) assays were conducted on HLTY ECFCs transduced with lentivirus expressing miR-146a-5p (middle panel) and miR-146b-5p (right panel). (F) Quantification data of (E). n.s: not significant, *p<0.05, **p<0.01 by <i>Student’s-t</i> test.