Expression of HIV receptors in progenitor cells.

<p>A. Affymetrix array data of gene expression in human bone marrow stem and differentiated cell types extracted from a published data set [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006509#ppat.1006509.ref012" target="_blank">12</a>] accessed via the NCBI Gene Expression Omnibus database (GSE42519). Left panel, heat map representing the z-score (scaled for each column) of the log transformed gene expression data. Right panel, relative expression levels of HIV receptors in each subset. The original microarray data went through background correction, normalization, and log transformation via the RMA method. For the right panel, data was converted from log transformed to linear. B. RNA seq analysis of mouse bone marrow and differentiated cell types. Left panel, heat map representing the z-score (scaled for each column) of the log transformed gene expression data. Right panel, relative expression levels of HIV receptors in each subset. Mean ± SEM is shown. (Abbreviations: FC, fold change; HSC, hematopoietic stem cell; MPP, multipotent progenitor; CMP, common myeloid progenitor; GMP, granulocyte-monocyte progenitor; MEP, megakaryocyte-erythrocyte progenitor; PM, promyelocyte; MY, myelocyte; MM, metamyelocytes; BC, band cell; PMN, polymorphonuclear cells; GR, granulocyte; ProB, pro-B cell; PreB, pre-B cell; BM, unfractionated bone marrow. FPKM, Fragments Per Kilobase Of Exon Per Million Fragments Mapped) (*<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001, ****<i>p</i><0.0001, 2-tailed unpaired t test).