ADCC titers in vaccinated macaques in Groups 1 and 2.
- Mauricio A. Martins (102761)
- Young C. Shin (4264840)
- Lucas Gonzalez-Nieto (4102363)
- Aline Domingues (4102369)
- Martin J. Gutman (4102366)
- Helen S. Maxwell (4102396)
- Iris Castro (45088)
- Diogo M. Magnani (4102390)
- Michael Ricciardi (4264846)
- Nuria Pedreño-Lopez (4264831)
- Varian Bailey (4264834)
- Dillon Betancourt (4264843)
- John D. Altman (282913)
- Matthias Pauthner (3075156)
- Dennis R. Burton (106420)
- Benjamin von Bredow (4264837)
- David T. Evans (140189)
- Maoli Yuan (629173)
- Christopher L. Parks (102790)
- Keisuke Ejima (402068)
- David B. Allison (49148)
- Eva Rakasz (313904)
- Glen N. Barber (304532)
- Saverio Capuano III (3375143)
- Jeffrey D. Lifson (140183)
- Ronald C. Desrosiers (140185)
- David I. Watkins (36142)
Publication date
July 2017
DOIAbstract
<p>Plasma collected from vaccinated macaques in Groups 1 (A) and 2 (B) at the time of the first SIV challenge was screened for ADCC activity against SIVmac239-infected target cells (pink, green, and blue lines). SHIV<sub>AD8-E0</sub>-infected cells were used as internal controls for non-specific killing (black lines). The decrease in relative light units indicates the loss of virus-infected cells in the presence of an NK cell line during the duration of the assay. Dashed lines denote 50% activity. C) Plasma from an SIV-infected rhesus macaque (382–03) with a defined ADCC titer against SIVmac239-infected cells was used as a positive control for these measurements.</p
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