Second Window ICG in murine model.

<p>A) Signal to background ratio for mice in both 5.0mg/kg group and 2.5mg/kg group plotted versus time of imaging after ICG tail vein infusion. Point estimates at each time point represent average SBRs of the 10 mice in each group. Standard error bars are included. B) Illustration of mouse brain tumor 3 hours after administration of ICG (left) compared to control (no ICG infusion) mouse (right). Regions of interests used for quantifying fluorescence using LivingImage software are also shown. C) Coronal slice of animal’s entire brain stained with H&E. D) Epifluorescence microscopy of NIR signal in established tumor within mouse model.