Oligonucleotide design.

<p>(A) Schematic representation of the human dystrophin gene and sequence alignment of two exon 51 regions across the indicated species. Conserved nucleotide sequences are shadowed. (B) Annealing sites of SSOs designed in this study are indicated by boxes. For comparison, the annealing sites of Eteplirsen and Drisapersen are indicated by shaded boxes. Position +1 corresponds to the first nucleotide in exon 51.