Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses - Fig 5

<p><b>Antiviral effect of IFN-λ1 in Calu-3 cells as measured by cell ELISA (A) and by virus reduction assay (B).</b> *<i>P</i> < 0.05, °<i>P</i> < 0.01, compared to the values for the parental CA/04 virus. <b>(C) Replication efficiencies of the CA/04, CA/04-NA</b>^<b>S79L</b>, <b>CA/04-NA</b>^<b>K331N</b>, <b>and CA/04-NA</b>^{<b>S79L,K331N</b>} <b>viruses in Calu-3 cells.</b> *<i>P</i> < 0.05, °<i>P</i> < 0.01, compared to the values for the CA/04 virus. <b>(D) NA enzyme kinetics of CA/04, CA/04-NA</b>^<b>S79L</b>, <b>CA/04-NA</b>^<b>K331N</b>, <b>and CA/04-NA</b>^{<b>S79L,K331N</b>} <b>viruses.</b> Substrate conversion velocity (<i>V</i>_i) of NA was measured as a function of substrate concentration.