Enhanced nicotine oral SA in mice with vMB α4 deletion.

<p>a) Mean (± SEM) nicotine intake (mg/kg) over 4 days is shown for each nicotine concentration, in male and female α4-flox GFP(+) (n = 26) and Cre(+) (n = 24) mice. *<i>p</i><0.05. b) Mean (± SEM) nicotine intake ratio (fraction of nicotine-containing fluid consumed relative to total fluid consumed) over 4 days is shown for each nicotine concentration in α4-flox GFP(+) and Cre(+) mice. c) Mean (± SEM) intake of nicotine solution (mL/kg), used to calculate mass of nicotine intake shown in (a), is shown for each nicotine concentration in α4-flox GFP(+) and Cre(+) mice. d) Mean (± SEM) water intake (mL/kg) over 4 days is shown for each nicotine concentration in α4-flox GFP(+) and Cre(+) mice. e) Mean (± SEM) total fluid intake (mL/kg) over 4 days is shown for each nicotine concentration in GFP(+) and Cre(+) mice. f) Mean (± SEM) body weight (g) for α4-flox GFP(+) and Cre(+) mice is shown for each nicotine concentration. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182142#pone.0182142.s002" target="_blank">S2</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182142#pone.0182142.s003" target="_blank">S3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182142#pone.0182142.s004" target="_blank">S4</a> Figs show intake data separated by sex.