ONC201 modulates stem cell-related gene expression.
- Varun V. Prabhu (4018214)
- Amriti R. Lulla (4325869)
- Neel S. Madhukar (686392)
- Marie D. Ralff (4018196)
- Dan Zhao (285025)
- Christina Leah B. Kline (4325875)
- A. Pieter J. Van den Heuvel (4325872)
- Avital Lev (4018193)
- Mathew J. Garnett (811548)
- Ultan McDermott (213251)
- Cyril H. Benes (408440)
- Tracy T. Batchelor (353983)
- Andrew S. Chi (235603)
- Olivier Elemento (7617)
- Joshua E. Allen (388428)
- Wafik S. El-Deiry (388432)
Publication date
August 2017
DOIAbstract
<p>(A) Summary of targeted network analysis of stem cell-related changes in ONC201-treated (10 μM) HCT116 p53-null cells by Ingenuity Pathway Analysis. The—log(p-value) is indicated for each group of genes. Ratio indicates the relative number of genes that were significantly changed upon ONC201 treatment compared to total number of genes in the group. (B) qRT-PCR for indicated stem cell-related genes in DMSO/ONC201-treated (5 μM, 18 h/48 h, n = 3) HCT116 p53-null cells. * indicates p < 0.02 relative to DMSO.</p
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