Linagliptin increases Egr1 in cardiac tissue.

<p>(A) DNA microarray analysis data for cardiac tissues. KEGG categories enriched by 1.5-fold in mice on a high fat diet (HFD) receiving linagliptin, a DPP-4 inhibitor (HFD+DPP-4i) (n = 3), compared to untreated HFD mice (n = 3) are described. (B) In DNA microarray analysis, transcripts with GO terms such as “Angiogenesis”, “Vessel” or “Hypoxia” were extracted. The top 9 molecules showing higher expression in HFD+DPP-4i mice compared to untreated HFD mice are displayed [normal chow (NC) (n = 3), HFD (n = 3) and HFD+DPP-4i(n = 3)]. (C) Quantitative PCR for <i>Egr1</i> in cardiac tissues of the indicated mice (n = 6,6,6). Data were analyzed by the 2-tailed Student’s t-test (A, B), or 2-way ANOVA followed by Tukey’s multiple comparison test (C). *P<0.05, **P<0.01. All values represent the mean ± s.e.m. NS = not significant.