Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury - Fig 8

<p>(A) iPS-NSC transplant combined with ChABC pretreatment improves recovery of forelimb grip strength in chronic SCI. Data are normalized to pretreatment (post-injury) baseline function with 1 representing no difference after treatment and values above 1 indicating improvement. The graph demonstrates a trend towards improvement (bar above 1) with ChABC or iPS-NSC treatment alone, however, only the combinatorial treatment with both resulted in statistically significant recovery across most post-treatment time points (p<0.05). Data represented as mean ± SEM. n = 15 per group. (*) indicates statistical significance for the iPS-NSC + ChABC group. (†) indicates significance for the iPS-NSC group. (B-D) Combined ChABC and iPS-NSC enhances CatWalk digital gait analysis outcomes. Data are normalized to pretreatment (post-injury) baseline function with 1 representing no difference after treatment and values above 1 indicating improvement. All comparisons are made against the control (injury alone) group. (B) Significant increases were seen in forelimb swing speed for the combinatorial treatment group only (p<0.05). Hindlimb swing speed improvements in the combinatorial group also reached statistical significance but only at the first two assessments (p<0.05). (C) Forelimb paw print area improved at the 4, 6, and 8-week time points in both the iPS-NSC and iPS-NSC + ChABC groups (p<0.05). Hindlimb paw print area only improved in the combinatorial group reaching statistical significance at the first three assessment time points (p<0.05). (D) The combinatorial group showed a nonsignficant trend towards improvement in forelimb stride length as well but not hindlimb stride length. Data represented as mean ± SEM n = 15 per group. (*) indicates statistical significance for the iPS-NSC + ChABC group. (†) indicates significance for the iPS-NSC group. (Ω) indicates significance for the ChABC group.