Domain organization of LytS/LytTR histidine kinase/response regulator.

<p>HKs of the LytS family contain a 5TM-5TMR_LYT domain (pfam07694) and a GAF domain, which together form the input domain. The cytosolic DHp [harboring a conserved histidine (His)] and CA modules in the HKs serve as the transmitter domain. The RR belongs to the LytTR-type family of transcriptional activators and comprises a CheY-like receiver domain [harboring a conserved aspartate (Asp)], and a LytTR-type effector domain made up of a 10-stranded β-fold DNA-binding domain.