This figure shows data from the six studies testing an anti-toxin agent in more than one experiment in the same species, as well as the overall effects anti-toxin agents had on the relative risk of death (95%CI) (RR) across each of these 6 groups of experiments and the I² and its level of significance for the consistency of these overall effects.

<p>Individual RRs for experiments are shown by the squares and overall RRs are shown by the inverted triangles. In the six studies shown, AVP-21D9 (AVP) was studied in four experiments in the guinea pig (Gpig); Anthrax Immune Globulin (AIG) in eight experiments in the rabbit and two experiments in the monkey; and ETI-204 (ETI) in two experiments in the rabbit and two in the monkey. In the five studies testing AIG or ETI, these agents had very consistent effects on the side of benefit across experiments (I² = 0, p≥0.56) in the same species. In the four experiments testing AVP-21D9 in guinea pigs, the RR was also on the side of decreasing mortality but the I² value was moderate although not significant. Control treatments were antibiotics + the following; *no placebo was described; **human intravenous globulin (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182879#pone.0182879.t002" target="_blank">Table 2</a>).