Dendritic cells infiltrating the intestinal mucosa of young patients with IBD produce TNF-α and IFN-γ.

<p>Intestinal dendritic cells (DC) were evaluated as CD11c positive cells. Overall frequencies and representative dot plots of CD11c positive cells detected in intestinal mucosa from Crohn’s disease (CD), ulcerative colitis (UC), and non-IBD controls are shown. (<b>A and B</b>) The frequencies of CD11c positive cells expressing the HLA DR activation marker (<b>C</b>), and producing TNF-α (<b>D</b>),or IFN-γ (<b>E</b>) are shown. All data are referred to the cell infiltration observed in intestinal biopsies at basal, unstimulated condition. Horizontal bars are the median values. The Mann-Whitney U test was applied to evaluate statistical significant differences.