Additional file 5: Table S1. of Development of pathogenicity predictors specific for variants that do not comply with clinical guidelines for the use of computational evidence

Success rate of the coincidence rule, for the all the different combinations of reference predictors (SIFT, PolyPhen-2, PON-P2, CADD and MutationTaster2). The performance measures are the six standard measures (MCC, accuracy, sensitivity, specificity, PPV and NPV) described in the Materials and Methods section. We give: the raw TP, TN, FP and FN values; the coverage relative to the original dataset of 59,442 variants (VS228) and the number of cases where the predictors coincide. (PDF 28 kb