Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome - Fig 4

<p>Simulation results of five chromosomes, <i>M</i> = 35,760, <i>N</i> = 10,000, <i>p</i> = 250: left-top figure is of <i>h</i>² = 0.1, left-bottom figure is of <i>h</i>² = 0.6; in the left figures colored bar represents the mean of estimated heritability, and vertical black bars are mean ± two standard errors; right figures present the relative efficiency (RE), and mean-squared error (MSE) × 10⁴. For HERRA and LDAK, RE is defined as the ratio of the variance of GCTA’s estimator to the respective variance of HERRA and LDAK estimators.