RP transcript deregulation in human cancers.

<p>3D area maps of transcript levels for 77 RPs expressed in HCCs (A), CRCs (B), BCs (C) and PCs (D). To better evaluate differences in the other transcripts which did reach significance for their F-tests, these transcripts–<i>Rps26</i>, <i>Rpl9</i>, <i>Rps27</i>, <i>Rps28</i>, and <i>Rpl21</i>– were excluded from 3D area plots. For each cancer, tumors with matched samples of normal tissue in TCGA were selected for direct comparison (50 for HCC, 41 for CRC, 113 for BC and 52 for PC). Relative expression for each RP transcript was calculated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182705#pone.0182705.g001" target="_blank">Fig 1</a>. See Figures D-G in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182705#pone.0182705.s001" target="_blank">S1 File</a> for 3D area plots of the above matched tumor data together with additional data from unmatched tumor samples. (E, F) Patient survival in HCC and BC inversely correlates with the severity of RP transcript deregulation. Patients were sorted according to their RP transcript deregulation, and survival curves were plotted for the top and bottom 25% of patients with the greatest and least degree of RP transcript deregulation.