<p>(<b>A</b>) H&E staining of proliferative vessels (red arrows) observed on the surface of the peripheral retina of a PSR eye. (<b>B</b>) Non-staining IgG (negative control). (<b>C</b>) CD34 staining (vascular endothelial cells) of proliferative vessels (red arrows) overlying non-perfused (i.e., no CD34 staining of retinal vessels) peripheral retina (blue arrows). (<b>D</b>) ANGPTL4 staining within non-perfused (i.e., no CD34 staining of retinal vessels) peripheral retina (orange arrows) and in the vascular endothelial cells and within the stroma (red arrows) of the retinal neovascular tissue overlying the peripheral non-perfused retina. Similar results were obtained in 5/5 PSR eyes tested.</p
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily...
<p>These factors were found preferentially in the retina and additionally in nerves and in the RPE. ...
<p>(A-D) Immunostaining for Robo1 (A), VEGF (B), and DAPI (C) inFVMs from eyes with PDR. Staining in...
The recent success of therapies directly targeting the angiogenic mediator, vascular endothelial gro...
<p><b>A</b>) A time line depicting the stages of retinal layer vascularization with diagrams of appr...
Proper vessel maturation, remodeling of endothelial junctions, and recruitment of perivascular cells...
<p>(A) qPCR quantification of FABP4 mRNA in total retinas from P12 to P17 in control (RA = room air)...
<p><b>(a-d) Confocal microscopy of vascular abnormalities within the neural retina, one month after ...
<p>Retinal sections stained for pSmad1/5/8 (green) reveal Smad1/5/8 activation in vascular cells and...
<p>(A-C) <i>Sox7</i> (A), <i>Sox17</i> (B), and <i>Sox18</i> (C) are expressed in ECs as determined ...
<p>Following OIR, mice were perfused with RCA-1-FITC to detect perfused vessels immediately prior to...
<p>(A) Diagram of trabecular meshwork and Schlemm’s canal endothelial cells (aqueous flow, red; trab...
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily...
<p>Representative photos of Aβ<sub>1–42</sub> immunostaining on retinal sections in non-AOH control ...
<p>(A) qPCR quantification of FABP4 mRNA in total retinas from P1 to P33 WT mice. Results are expres...
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily...
<p>These factors were found preferentially in the retina and additionally in nerves and in the RPE. ...
<p>(A-D) Immunostaining for Robo1 (A), VEGF (B), and DAPI (C) inFVMs from eyes with PDR. Staining in...
The recent success of therapies directly targeting the angiogenic mediator, vascular endothelial gro...
<p><b>A</b>) A time line depicting the stages of retinal layer vascularization with diagrams of appr...
Proper vessel maturation, remodeling of endothelial junctions, and recruitment of perivascular cells...
<p>(A) qPCR quantification of FABP4 mRNA in total retinas from P12 to P17 in control (RA = room air)...
<p><b>(a-d) Confocal microscopy of vascular abnormalities within the neural retina, one month after ...
<p>Retinal sections stained for pSmad1/5/8 (green) reveal Smad1/5/8 activation in vascular cells and...
<p>(A-C) <i>Sox7</i> (A), <i>Sox17</i> (B), and <i>Sox18</i> (C) are expressed in ECs as determined ...
<p>Following OIR, mice were perfused with RCA-1-FITC to detect perfused vessels immediately prior to...
<p>(A) Diagram of trabecular meshwork and Schlemm’s canal endothelial cells (aqueous flow, red; trab...
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily...
<p>Representative photos of Aβ<sub>1–42</sub> immunostaining on retinal sections in non-AOH control ...
<p>(A) qPCR quantification of FABP4 mRNA in total retinas from P1 to P33 WT mice. Results are expres...
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily...
<p>These factors were found preferentially in the retina and additionally in nerves and in the RPE. ...
<p>(A-D) Immunostaining for Robo1 (A), VEGF (B), and DAPI (C) inFVMs from eyes with PDR. Staining in...