Change from baseline in maximum voluntary ventilation (MVV). Mean changes from baseline to week 72 in subjects receiving 20Â mg/kg reveglucosidase alfa infusion every 2Â weeks. Baseline is defined as the last measurement prior to the first infusion. The error bars represent the standard deviations. The statistical significance of treatment effects was not determined, as no pre-planned statistical analyses were conducted for this study. (PDF 122Â kb
Online supplement - Table S1. PtCO2 change âĽ4 mmHg according to randomised treatment. Table S2. S...
Figure S1. Comparison of area under curves of serial troponin I and creatine kinase-MB measurements ...
Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety...
Study design; Additional Fig. 1. Study design schematic; Additional Fig. 2. Mean change from baselin...
Table S1. Pivotal trials with at least one postapproval trial with a patient-relevant outcome. (XLSX...
Cohort counts by month of UMEC/VI initiation (Nâ=â2200). Additional figure illustrating the numb...
Figure S1. Post hoc analysis of RVSP using mean difference (MD). Figure S2. Post hoc analysis of RVS...
Table S1. Summary of sensitive analysis for prophylaxis efficacy. Figure S1. Source of bias in two r...
Figure S1. CK values measured over time for patient 1 (circle), patient 2 (square) and patient 3 (tr...
Figure S3. Meta-analysis of overall pooled WMDs with 95% CIs across studies for secondary outcomes i...
Supplemental Tables. Studies excluded with reasons. Data regarding baseline patient characteristics,...
White blood cells (cells/μL) expressed as mean ± SD at the beginning (V1), after 2 weeks (V2) and af...
Figure S1. Assessment of risk of bias in included trials. Figure S2. Forrest plot based on aggregate...
Study design Figure. Abbreviations: BDI, Baseline Dyspnoea Index; CAT, COPD Assessment Test; FP/SAL,...
Publication bias for the primary outcomes. A Begg's funnel plot for mortality. b Begg's funnel plot ...
Online supplement - Table S1. PtCO2 change âĽ4 mmHg according to randomised treatment. Table S2. S...
Figure S1. Comparison of area under curves of serial troponin I and creatine kinase-MB measurements ...
Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety...
Study design; Additional Fig. 1. Study design schematic; Additional Fig. 2. Mean change from baselin...
Table S1. Pivotal trials with at least one postapproval trial with a patient-relevant outcome. (XLSX...
Cohort counts by month of UMEC/VI initiation (Nâ=â2200). Additional figure illustrating the numb...
Figure S1. Post hoc analysis of RVSP using mean difference (MD). Figure S2. Post hoc analysis of RVS...
Table S1. Summary of sensitive analysis for prophylaxis efficacy. Figure S1. Source of bias in two r...
Figure S1. CK values measured over time for patient 1 (circle), patient 2 (square) and patient 3 (tr...
Figure S3. Meta-analysis of overall pooled WMDs with 95% CIs across studies for secondary outcomes i...
Supplemental Tables. Studies excluded with reasons. Data regarding baseline patient characteristics,...
White blood cells (cells/μL) expressed as mean ± SD at the beginning (V1), after 2 weeks (V2) and af...
Figure S1. Assessment of risk of bias in included trials. Figure S2. Forrest plot based on aggregate...
Study design Figure. Abbreviations: BDI, Baseline Dyspnoea Index; CAT, COPD Assessment Test; FP/SAL,...
Publication bias for the primary outcomes. A Begg's funnel plot for mortality. b Begg's funnel plot ...
Online supplement - Table S1. PtCO2 change âĽ4 mmHg according to randomised treatment. Table S2. S...
Figure S1. Comparison of area under curves of serial troponin I and creatine kinase-MB measurements ...
Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety...