Influence of recombinant human collagen-based microspheres on conduction slowing mediated by a contact based mechanism.

<p>Activation maps of <b>A:</b> monolayers of NRVM cultured with rASC and rASC loaded microspheres, respectively. The effect on conduction velocity (<b>B</b>) and conduction heterogeneity (<b>C</b>) are determined along the white arrows perpendicular to isochronal (black) lines. Activation maps of <b>D</b>: monolayers of NRVM cultured with hASC and hASC loaded microspheres, respectively. The effect on conduction velocity (<b>E</b>) and conduction heterogeneity (<b>F</b>) are determined along the white arrows perpendicular to isochronal (black) lines.* indicates p< 0.001 compared to the monolayers of NRVM. Number of replicates per experimental condition is indicated in the bar-graphs. Abbreviations; hASC: human adipose tissue-derived stromal cells, MS: microspheres, NRVM: neonatal rat ventricular myocytes, and rASC: rat adipose tissue-derived stromal cells.