Synaptic density following ND-602.

<p><b>(A)</b> Representative fluorescent photomicrographs depicting immunolabeling for the synaptic protein, synaptophysin, in the dentate gyrus and CA1 region of the hippocampus, following lentiviral delivery of LV-GFP or LV-PGRN (ND-602). Immunolabeling of synaptophysin was significantly reduced in the <b>(B)</b> dentate gyrus and <b>(C)</b> CA1 region of the hippocampus of Tg2576 mice, as compared to wild-type controls. Density of synaptophysin labeling was significantly increased in both regions following administration of ND-602. Each bar represents the mean (± S.E.M., <i>n</i> = 5–10) optical density measured. ** sig. diff. from GFP-treated controls, <i>p</i> < 0.001; * <i>p</i> < 0.05. + sig. diff. from wild-type controls, <i>p</i> < 0.05.