Additional file 7: Figure S5. Permutation test to assess the significance of the literature-based validation. Ten thousands permutations of the Fisher’s exact test were run using random labels. Histograms show distributions of (A) p values (mean = 0.41, standard deviation = 0.42) and (B) odds ratios (mean = 1.00, standard deviation = 0.08)
Dataset used for testing the calibration of 6 methods for predicting the impact of single nucleotide...
PURPOSE: Where multiple in silico tools are concordant, the American College of Medical Genetics and...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
Additional file 4: Figure S4. Monte Carlo simulation to assess the effect of randomly sampling from ...
<p>(A) The knowledge (OMIM)-based method. The list of OMIM numbers related to cancer (e.g., cancer, ...
Names have been shortened by removing the “bioseq2” prefix for all of them. (A) Inter-replicate agre...
We are now in a new era. The recent completion of the entire sequence of the human genome and high-t...
<p>The full dataset is a gene expression matrix with 8,000 features (the genes) as rows and 30 sampl...
Purpose: Where multiple in silico tools are concordant, the American College of Medical Genetics and...
<p><b>Copyright information:</b></p><p>Taken from "Prediction of potential drug targets based on sim...
Figure S1. P value distributions calculated as part of the generation of predictive models for metab...
Powerful methods for integrated analysis of multiple biological data sets are needed to maximize int...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
This thesis addresses important statistical challenges in precision medicine, the clinical practice ...
<p>MDR, multifactor dimensionality reduction.</p>a<p><i>P</i> value for 1000-fold permutation test. ...
Dataset used for testing the calibration of 6 methods for predicting the impact of single nucleotide...
PURPOSE: Where multiple in silico tools are concordant, the American College of Medical Genetics and...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
Additional file 4: Figure S4. Monte Carlo simulation to assess the effect of randomly sampling from ...
<p>(A) The knowledge (OMIM)-based method. The list of OMIM numbers related to cancer (e.g., cancer, ...
Names have been shortened by removing the “bioseq2” prefix for all of them. (A) Inter-replicate agre...
We are now in a new era. The recent completion of the entire sequence of the human genome and high-t...
<p>The full dataset is a gene expression matrix with 8,000 features (the genes) as rows and 30 sampl...
Purpose: Where multiple in silico tools are concordant, the American College of Medical Genetics and...
<p><b>Copyright information:</b></p><p>Taken from "Prediction of potential drug targets based on sim...
Figure S1. P value distributions calculated as part of the generation of predictive models for metab...
Powerful methods for integrated analysis of multiple biological data sets are needed to maximize int...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
This thesis addresses important statistical challenges in precision medicine, the clinical practice ...
<p>MDR, multifactor dimensionality reduction.</p>a<p><i>P</i> value for 1000-fold permutation test. ...
Dataset used for testing the calibration of 6 methods for predicting the impact of single nucleotide...
PURPOSE: Where multiple in silico tools are concordant, the American College of Medical Genetics and...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...