Viral load of RAG^-/- mice after therapy with neutralizing antibodies.

<p>Mice were infected with 10⁵ pfu MCMV157luc and treated with the indicated mAbs three days after infection. A total of 250 μg IgG or 200 μl serum per animal was injected. Viral load in aliquots of organ homogenates containing 30 μg protein was determined ten days after infection by a luciferase based assay. RLU: relative light units. Statistics: One way ANOVA using Bonferroni´s multiple comparison test *: p<0.05, **: p<0.01, ***: p<0.001, ****: p<0.0001. Dotted line: detection limit. Representative data from 3 independent experiments. Apart from the statistics shown in the figure there were also statistical differences between M11/97.3 vs 27.7/1F11 in liver (p<0.05), kidney (p<0.01) and salivary gland (p<0.05). Differences in lung were not statistically significant.