<p>Relative growth values for 35 <i>S</i>. <i>aureus</i> strains derived from the MBT-ASTRA assay performed with ciprofloxacin are shown. A relative growth cutoff of 0.5 was utilized to classify resistance, indicated by the horizontal line. Strains are arranged from left to right in order of increasing MIC, with exact values given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183899#pone.0183899.t001" target="_blank">Table 1</a>. Data points colored red indicate major or very major errors. For each strain, 4–6 independent replicates were obtained on different days.</p
Objectives: For fluoroquinolones, the area under the free plasma concentration-time curve divided by...
The emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive an...
<p>The growth curves measured by plating for CFU of the drug resistant and susceptible strains in 7H...
Measurements of ciprofloxacin resistance for all strains and populations used in this study. Resista...
Measurements of ciprofloxacin resistance for all strains and populations used in this study. Resista...
<p>In panel A, the experiment was performed with an initial inoculum of 10<sup>7</sup> CFU/ml of eac...
<p>Strains were exposed to ciprofloxacin in exponential growth phase. Viable counts were determined ...
<p>(A) Survival of wild-type cells in exponential phase under different ciprofloxacin regimes. Two c...
a<p>Mutation rates (<i>µ</i>) per replication and 95% confidence limits (CL) were calculated as desc...
The MIC values (mg/l) are marked to the external nodes with corresponding strain names. Strains with...
<p>Box and whisker plots show the range of ciprofloxacin MICs for FQS and FQR clinical isolates. Dat...
Objectives: For fluoroquinolones, the area under the free plasma concentration-time curve divided by...
The phenotypic resistance of selected organisms to ciprofloxacin, levofloxacin, and trovafloxacin wa...
<p>Ciprofloxacin (CIP); chloramphenicol (CHL); erythromycin (ERY); gentamicin (GEN); kanamycin (KAN)...
<p>Depicted are rhomboid mutants (Δ4904, Δ5036 and Δ4904Δ5036) and the wild type (WT) cultured in me...
Objectives: For fluoroquinolones, the area under the free plasma concentration-time curve divided by...
The emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive an...
<p>The growth curves measured by plating for CFU of the drug resistant and susceptible strains in 7H...
Measurements of ciprofloxacin resistance for all strains and populations used in this study. Resista...
Measurements of ciprofloxacin resistance for all strains and populations used in this study. Resista...
<p>In panel A, the experiment was performed with an initial inoculum of 10<sup>7</sup> CFU/ml of eac...
<p>Strains were exposed to ciprofloxacin in exponential growth phase. Viable counts were determined ...
<p>(A) Survival of wild-type cells in exponential phase under different ciprofloxacin regimes. Two c...
a<p>Mutation rates (<i>µ</i>) per replication and 95% confidence limits (CL) were calculated as desc...
The MIC values (mg/l) are marked to the external nodes with corresponding strain names. Strains with...
<p>Box and whisker plots show the range of ciprofloxacin MICs for FQS and FQR clinical isolates. Dat...
Objectives: For fluoroquinolones, the area under the free plasma concentration-time curve divided by...
The phenotypic resistance of selected organisms to ciprofloxacin, levofloxacin, and trovafloxacin wa...
<p>Ciprofloxacin (CIP); chloramphenicol (CHL); erythromycin (ERY); gentamicin (GEN); kanamycin (KAN)...
<p>Depicted are rhomboid mutants (Δ4904, Δ5036 and Δ4904Δ5036) and the wild type (WT) cultured in me...
Objectives: For fluoroquinolones, the area under the free plasma concentration-time curve divided by...
The emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive an...
<p>The growth curves measured by plating for CFU of the drug resistant and susceptible strains in 7H...