<p>Superposition of initial structures of Cldn15 used in the monomer and the single-pore (Model1) and the double-pore (Model2) simulations. The identical folding is pictured in pink, while the two different conformations of loops ECL1 and ECL2 are colored in brown for Model1 and cyan for Model2. Secondary structure elements are labeled in black and red.</p
<p>(A) Model showing the hypothesized conformational changes taking place at LBD and TM domain in bi...
<p>A gp45 monomer (A) and (B) dimer are represented in ribbon form and as “spheres and arrows” as de...
<p><b>(A)</b> Molecular dynamics trajectories of the wild-type, V630del mutant and V630 hybrid CLZ d...
<p><b>A:</b> Front (top row) and side (bottom row) views of snapshots taken at 0, 2.5, 5, 7.5, and 1...
Structural elements relevant for defining a more open or closed conformation are the regions of the ...
<p>(A) Homology model of ClC-Kb using ClC-ec1 (1OTS) as a template for the membrane domain and the C...
<p>Side view showing the position of the C-terminal and N-terminal. Top view showing the backbone pa...
<p>The two chains are represented as cartoons in light or dark grey. F119 on one chain and L119 on t...
<p>The experimental structures are colored red, the predicted loops are green, and the first 20 stru...
<p>Initial conformation shown in (A) or after 200 ns of equilibration for models of type 1 (B), type...
<p>The models are represented as ribbons, with WT colored in pink-salmon and T190M colored in blue; ...
<p>Ribbon representation of the Cldn15 crystal structure (PDB code 4P79). The black bars indicate th...
<p><b>Copyright information:</b></p><p>Taken from "Can molecular dynamics simulations help in discri...
<p>(A) Model reconstructions of PgdS in solution. Right: <i>ab initio</i> models from DAMMIF model; ...
<p>A - Superposition of the initial structure (red) vs. the most favorable conformation of a simulat...
<p>(A) Model showing the hypothesized conformational changes taking place at LBD and TM domain in bi...
<p>A gp45 monomer (A) and (B) dimer are represented in ribbon form and as “spheres and arrows” as de...
<p><b>(A)</b> Molecular dynamics trajectories of the wild-type, V630del mutant and V630 hybrid CLZ d...
<p><b>A:</b> Front (top row) and side (bottom row) views of snapshots taken at 0, 2.5, 5, 7.5, and 1...
Structural elements relevant for defining a more open or closed conformation are the regions of the ...
<p>(A) Homology model of ClC-Kb using ClC-ec1 (1OTS) as a template for the membrane domain and the C...
<p>Side view showing the position of the C-terminal and N-terminal. Top view showing the backbone pa...
<p>The two chains are represented as cartoons in light or dark grey. F119 on one chain and L119 on t...
<p>The experimental structures are colored red, the predicted loops are green, and the first 20 stru...
<p>Initial conformation shown in (A) or after 200 ns of equilibration for models of type 1 (B), type...
<p>The models are represented as ribbons, with WT colored in pink-salmon and T190M colored in blue; ...
<p>Ribbon representation of the Cldn15 crystal structure (PDB code 4P79). The black bars indicate th...
<p><b>Copyright information:</b></p><p>Taken from "Can molecular dynamics simulations help in discri...
<p>(A) Model reconstructions of PgdS in solution. Right: <i>ab initio</i> models from DAMMIF model; ...
<p>A - Superposition of the initial structure (red) vs. the most favorable conformation of a simulat...
<p>(A) Model showing the hypothesized conformational changes taking place at LBD and TM domain in bi...
<p>A gp45 monomer (A) and (B) dimer are represented in ribbon form and as “spheres and arrows” as de...
<p><b>(A)</b> Molecular dynamics trajectories of the wild-type, V630del mutant and V630 hybrid CLZ d...