Diet-based comparisons of enzyme expression in pantothenate pathway. Two comparisons are shown: (A) Plin2-HF vs. Plin2-LF and (B) WT-HF vs. WT-LF. Circular nodes indicate enzymes, with size indicating relative difference in expression between sample types and color indicating direction of change (see inset key). Associated heatmaps indicate global changes in expression for each enzyme, in addition to taxon-specific changes in expression for each of the 17 defined taxa colored according to phylum. The following abbreviations are used: 5,6-dh-uracil (5,6-dihydro-uracil), N-cm-β-alanine (N-carbamoyl-β-alanine), N-pt-Cys (N-pantothenoyl-cysteine), and (R)-4′-P-pt-L-Cys ((R)-4′-phospho-pantothenoyl-l-cysteine. (PDF 1119 kb
Figure S1. Detection of perilipin via western blot analysis. A – SDS-PAGE was carried out as describ...
Count of genes that responded in a significant, dose-dependent way to fat intake (model selection ba...
Figure S2. Impact of experimental feedings and microbial colonization on mouse metabolism. a Body we...
Genotype-based comparisons of pantothenate pathway enzyme expression. Two comparisons are shown: (A)...
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Over-represented Gene Ontology Biological Process (GOBP) terms associated with differentially expres...
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Relative abundance of KOs in relation to mouse strain and diet. Most of the annotated KOs is involve...
Figure S1. Detection of perilipin via western blot analysis. A – SDS-PAGE was carried out as describ...
Count of genes that responded in a significant, dose-dependent way to fat intake (model selection ba...
Figure S2. Impact of experimental feedings and microbial colonization on mouse metabolism. a Body we...
Genotype-based comparisons of pantothenate pathway enzyme expression. Two comparisons are shown: (A)...
Comparison of glycolysis pathway enzyme expression between sample types. Three comparisons are shown...
Comparison of TCA cycle enzyme expression in between sample types. Three comparisons are shown: (A) ...
Enrichment of sig. enzymes in 144 KEGG pathways for four pairwise comparisons (Plin2-HF vs. WT-HF, P...
Principal component analysis for four data types (Taxa, Enzymes, Significant Differentially Expresse...
Figure S2. Mouse adipose tissue gene expression. Bar plots showing the gene expression of (a) adipoq...
Over-represented Gene Ontology Biological Process (GOBP) terms associated with differentially expres...
The steep rise in both childhood and adult obesity over the past three decades has moved to the fore...
Betweenness centrality vs. Degree. For each node, we computed the degree and betweenness centrality....
Cladogram plot showing bacterial taxa with LDA scores higher than two using strict version of LEfSe....
Abstract Background Intestinal microbiota are critica...
Relative abundance of KOs in relation to mouse strain and diet. Most of the annotated KOs is involve...
Figure S1. Detection of perilipin via western blot analysis. A – SDS-PAGE was carried out as describ...
Count of genes that responded in a significant, dose-dependent way to fat intake (model selection ba...
Figure S2. Impact of experimental feedings and microbial colonization on mouse metabolism. a Body we...