Methylene C(sp<sup>3</sup>)–H Arylation of Aliphatic Ketones Using a Transient Directing Group
- Kai Hong (514257)
- Hojoon Park (3624998)
- Jin-Quan Yu (1303500)
Publication date
September 2017
DOIAbstract
Palladium-catalyzed methylene β-C(sp<sup>3</sup>)–H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp<sup>3</sup>)–H bond activation
Add to ORKG