Liver and intestine areas taken by inflammatory infiltrates in the natural and experimental infections with <i>S</i>. <i>mansoni</i>.

<p>(A) Representative image of hepatic tissue from a mouse experimentally infected. After acquisition of whole slide images, areas with inflammatory infiltrates (marked in red) outside typical granulomas (marked in green) were measured. In (B), morphometric analyses reveal a very low incidence of infiltrates in the liver of infected wild rodent (natural infection) while mice experimentally infected show a very high proportion of infiltrates. In the small intestine, infiltrates are moderately higher in the natural compared to the acute experimental infection. Different letters indicate significant differences between the means (<i>P</i> < 0.0001 for all comparisons between different letters in the respective groups).