Raster plots and time-dependent histograms of simulated postsynaptic spiking of the model, in response to <i>f</i> = 1 Hz modulated pre-synaptic population inputs for different synaptic configurations with depressing synapses.

<p>The first panel shows the pre-synaptic spike-rate modulation, λ_S(<i>t</i>). The second panel shows the spike times of 10 independently generated pre-synaptic spike trains with time-dependent inhomogenous Poisson rate λ_S(<i>t</i>). The third, fifth and seventh panels show 10 post-synaptic spike responses for three distinct synaptic configurations (<i>M</i> = 1, <i>M</i> = 4 and <i>M</i> = 32), in response to 10 sets of independent pre-synaptic spike-trains. The fourth, sixth and eighth panels show histograms of the number of post-synaptic spikes as a function of time, in 5 ms bins, from 100 independent input spike-trains, and 100 independent trials for the vesicle releases for each input spike-train.