<p>A polyglutamine expansion of the <i>N</i>-terminal region of huntingtin (Htt) causes Huntington’s disease, a severe neurodegenerative disorder. Htt huge multidomain structure, the presence of disordered regions, and the lack of sequence homologs of known structure, so far prevented structural studies of Htt, making the study of its structure-function relationships very difficult. In this work, the presence and location of five Htt ordered domains (named from Hunt1 to Hunt5) has been detected and the structure of these domains has been predicted for the first time using a combined threading/<i>ab initio</i> modeling approach. This work has led to the identification of a previously undetected HEAT repeats region in the Hunt3 domain. Furthe...
<p>A- The different domains of human Huntingtin protein (hHtt) are indicated: Polyglutamine tract (P...
SummaryWe used affinity-purification mass spectrometry to identify 747 candidate proteins that are c...
Huntington Disease (HD) is an autosomal dominant, neurodegenerative disorder with onset normally oc...
A polyglutamine expansion of the N-terminal region of huntingtin (Htt) causes Huntington’s disease, ...
Huntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD is caused by a ...
Huntington's disease (HD) is an autosomal dominant, fatal neurodegenerative disorder characterized b...
Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is inv...
Huntington’s disease (HD) is a neurodegenerative disorder which leads to death within a couple of de...
The polyQ expansion in huntingtin protein (HTT) is the prime cause of Huntington's disease (HD). The...
The huntingtin (HTT) protein plays critical roles in numerous cellular pathways by functioning as a ...
Abstract Background Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract...
Huntington's disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) ...
SummaryThe interactions of huntingtin (Htt) with the SH3 domain- or WW domain-containing proteins ha...
BACKGROUND: Huntingtons disease (HD) is a genetic neurodegenerative disease caused by trinucleotide ...
Huntington's disease results from genetically programmed degeneration of nerve cells, called ne...
<p>A- The different domains of human Huntingtin protein (hHtt) are indicated: Polyglutamine tract (P...
SummaryWe used affinity-purification mass spectrometry to identify 747 candidate proteins that are c...
Huntington Disease (HD) is an autosomal dominant, neurodegenerative disorder with onset normally oc...
A polyglutamine expansion of the N-terminal region of huntingtin (Htt) causes Huntington’s disease, ...
Huntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD is caused by a ...
Huntington's disease (HD) is an autosomal dominant, fatal neurodegenerative disorder characterized b...
Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is inv...
Huntington’s disease (HD) is a neurodegenerative disorder which leads to death within a couple of de...
The polyQ expansion in huntingtin protein (HTT) is the prime cause of Huntington's disease (HD). The...
The huntingtin (HTT) protein plays critical roles in numerous cellular pathways by functioning as a ...
Abstract Background Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract...
Huntington's disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) ...
SummaryThe interactions of huntingtin (Htt) with the SH3 domain- or WW domain-containing proteins ha...
BACKGROUND: Huntingtons disease (HD) is a genetic neurodegenerative disease caused by trinucleotide ...
Huntington's disease results from genetically programmed degeneration of nerve cells, called ne...
<p>A- The different domains of human Huntingtin protein (hHtt) are indicated: Polyglutamine tract (P...
SummaryWe used affinity-purification mass spectrometry to identify 747 candidate proteins that are c...
Huntington Disease (HD) is an autosomal dominant, neurodegenerative disorder with onset normally oc...