Antibody responses.

<p>(A) Patterns of binding Ab for the 3 immunization groups. Vertical dotted lines indicate immunizations. The horizontal dashed line compares troughs across immunizations. (B) Temporal peak titers of neutralizing Ab compared to peak titers of binding Ab (gray dashed line) in Group 1 animals. The patterns for A11R011 and A10L002 are typical for all animals that did not develop nAb to the CD4bs. (C). Mapping of neutralizing activity using mutants that knock out the V1V2 target for bnAb (N160A and N160A.N173A); the CH0505 target for bnAb to the CD4bs (N280D and G458Y); and the V3-glycan target for bnAb (N301A and N334A).