Coronary artery lesions in WHC-eTNAP mice.

<p><b>(A)</b> Consecutive sections of a left coronary artery (LCA) and a septal branch of the right coronary artery (RCA) from a 16-weeks-old WHC mouse with hypercholesterolemia (H&E staining). Both vessels are unaffected by atherosclerosis. <b>(B)</b> Consecutive sections of LCA and RCA from a 16-weeks-old WHC-eTNAP mouse with hypercholesterolemia (H&E staining). Both vessels are affected by atherosclerosis, with the RCA being severely stenotic. <b>(C)</b> Immunohistochemical detection of osteocalcin (green) in 16-weeks-old WHC and WHC-eTNAP mice with hypercholesterolemia. Sections were counterstain with DAPI (blue). <b>(D)</b> Sections containing the RCA from 13-weeks-old WHC and WHC-eTNAP mice with hypercholesterolemia were stained with picrosirius red for collagen. <b>(E)</b> Oil red O staining (red) of the LCA from 16-weeks-old WHC and WHC-eTNAP mice with hypercholesterolemia, counterstained with hematoxylin (purple).