Influence of the label size distribution on parameter estimation.

<p>(<b>A</b>) Examples of the three different distributions of label sizes investigated: Uniform, linear and exponential distribution (from top to bottom). Each distribution comprises a total of 1000 cells and 50 labels. The red dotted line indicates the average label size of 20 cells. (<b>B-C</b>) The difference in the MCIL for the estimation of the activation rate <i>μ</i> between the uniformly and linearly distributed labels (<b>B</b>), and the difference between uniformly and exponentially distributed labels (<b>C</b>). (<b>D</b>, <b>E</b>) Analogous to (<b>B</b>, <b>C</b>) the difference in the MCIL for the estimated proliferation rate <i>ρ</i>.