PVT data (open triangles) and simulations (filled circles) for Experiment 1, with time in bed (TIB) illustrated as gray bars.

<p>Panels show four experimental conditions: (A) Acute sleep deprivation with 0 h TIB, (B) 4 h TIB for 13 nights, then 2 nights of 8 h TIB, (C) 6 h TIB for 13 nights, then 2 nights of 8 h TIB, (D) 8 h TIB for 15 nights. PVT data were collected every 2 h during wakefulness, beginning 4 h after morning awakening, which was simulated to occur at 8am in all conditions (schedules from experimental data were shifted by 0.5 h for convenience). Zero time on the x-axis corresponds to midnight on the last baseline night. Data points are adapted from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005759#pcbi.1005759.ref017" target="_blank">17</a>].